SASP
The senescence-associated secretory phenotype: the inflammatory signals senescent cells pump out to damage neighbours.
At a glance
Key signals
100% cross fields · reaches 2 more
- Cell Biology
- Explanation
- Examples
- Misconception
- Sourced relations
- Attribution
Dependencies
What this concept builds on and what it makes possible — derived from the atlas’s dependency, causal and structural relations, not from every related edge.
Foundations · builds on
SASPemerges fromCellular senescenceEstablished
Senescent cells secrete harm.
Mechanism: A senescent cell broadcasts the inflammatory SASP that ages its neighbours.
Structural role & consequence
Interpreted from the current atlas graph — what the connections mean, not just how many there are.
100% of its relationships cross field boundaries, reaching 2 other disciplines — unusual in a discipline where most concepts stay within their field.
structural · Structural graph analysis — not a claim of importance, causation or history.
Currently dark in the atlas: no key date stored · 1 of 1 of its relations lack claim-level evidence.
atlas representation · Describes the current Thinking OS representation, not the state of the world.
Builds on 1 foundation (requires / depends-on / derived-from / emerges-from).
structural · Structural graph analysis — not a claim of importance, causation or history.
cross-field
0 within-field, 1 cross-field
Strengths & constraints
Strengths
- Cross-disciplinary connector — 100% of its relationships cross field boundaries. structural
Constraints
- Evidence coverage currently thin in the atlas — few of its relationships carry claim-level evidence. atlas representation
- No dated history stored — the atlas records no key date for this concept. atlas representation
Conditions
- Its dependency reading rests on 1 foundation relation. structural
- Read structurally — most of its relationships carry no external evidence yet, so claims here are graph-derived. structural
Dependency radial
What this concept builds on (left) and what it makes possible (right) — derived from dependency and causal relations.
Seen through each discipline
How this concept sits in each of its fields — derived from its real connections in the graph, not asserted.
Related ideas to explore
Concepts that look related but are not yet connected here — candidates for a connection to reason about, not established links.
This idea also appears in…
The same structure shows up in other disciplines. These are real recurrences drawn from the graph — a starting point for asking “what carries over, and what changes?”
Concepts
crosses a discipline boundary
- Connects 1 other ideas across 1 discipline.
- Most of its connections are of the “Cause & effect” kind.
Derived from the graph’s real structure — observations, not a score.