mTOR signaling
A nutrient-sensing kinase pathway that couples food abundance to growth versus repair; inhibiting it extends animal lifespan.
At a glance
Key signals
100% cross fields · reaches 4 more
- Cell Biology
- Biochemistry
- Explanation
- Examples
- Misconception
- Sourced relations
- Attribution
Structural role & consequence
Interpreted from the current atlas graph — what the connections mean, not just how many there are.
Removing this node severs the only sampled structural route between Caloric restriction and Gene expression — a non-redundant bridge here.
structural · Structural removal simulation — not a historical or causal counterfactual.
100% of its relationships cross field boundaries, reaching 4 other disciplines — unusual in a discipline where most concepts stay within their field.
structural · Structural graph analysis — not a claim of importance, causation or history.
Currently dark in the atlas: no key date stored · 3 of 3 of its relations lack claim-level evidence.
atlas representation · Describes the current Thinking OS representation, not the state of the world.
Structural neighbourhood: 3 → 14 → 43 concepts reachable within 3 hops.
structural · Structural reach — being reachable is not the same as being understood.
cross-field
0 within-field, 3 cross-field
Strengths & constraints
Strengths
- Cross-disciplinary connector — 100% of its relationships cross field boundaries. structural
Constraints
- Evidence coverage currently thin in the atlas — few of its relationships carry claim-level evidence. atlas representation
- Non-redundant bridge — removing it severs a sampled route between neighbouring clusters. structural
- No dated history stored — the atlas records no key date for this concept. atlas representation
Conditions
- Read structurally — most of its relationships carry no external evidence yet, so claims here are graph-derived. structural
Seen through each discipline
How this concept sits in each of its fields — derived from its real connections in the graph, not asserted.
Related ideas to explore
Concepts that look related but are not yet connected here — candidates for a connection to reason about, not established links.
This idea also appears in…
The same structure shows up in other disciplines. These are real recurrences drawn from the graph — a starting point for asking “what carries over, and what changes?”
Concepts
crosses a discipline boundary
- Caloric restrictionGerontology
crosses a discipline boundary
- RapamycinGerontology
crosses a discipline boundary
- Connects 3 other ideas across 2 disciplines.
- A cross-disciplinary bridge — its connections reach into 4 other fields.
- Most of its connections are of the “Cause & effect” kind.
Derived from the graph’s real structure — observations, not a score.
Sources
- Review: Schistosoma mansoni phosphatidylinositol 3 kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling pathway (2021) verified
- mTOR Signaling Pathways (2025) verified
- mTOR signaling in disease (2011) verified
- Immunoblotting-assisted assessment of JAK/STAT and PI3K/Akt/mTOR signaling in myeloproliferative neoplasms CD34+ stem cells (2022) verified